Inclusion Body Myositis Mimicking Motor Neuron Disease

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Inclusion body myositis mimicking motor neuron disease.

OBJECTIVE To describe the clinical and electrophysiologic features of patients with inclusion body myositis that was misinterpreted as motor neuron disease. PATIENTS AND METHODS We retrospectively retrieved the medical records of 70 patients with a pathologic diagnosis of inclusion body myositis. From this group, we selected those who had been first diagnosed as having motor neuron disease or...

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Granulomatous myositis mimicking slowly progressive lower motor neuron disease.

Here we illustrate a 74-year-old patient presenting with clinical signs of slowly progressive motor neuron disease. After electromyography demonstrated myopathic changes, a skeletal muscle biopsy was performed showing histological signs of granulomatous myositis. In extensive diagnostic workup underlying primary granulomas forming diseases were excluded and corticoid therapy was initiated, but ...

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Amyloid myoneuropathy mimicking inclusion body myositis.

myopathy affecting proximal and distal musculature with typical onset of symptoms after age 50 years. Inclusion body myositis more often affects males and results in a classical pattern of early asymmetric weakness and wasting of forearm flexors (wrist and long finger flexors), quadriceps and ankle dorsiflexors. Inclusion body myositis is more frequently associated with a monoclonal gammopathy ...

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Inclusion-Body Myositis Associated with Alzheimer's Disease

Sporadic inclusion-body myositis (s-IBM) is a myopathy that is characterized by progressive weakness and muscle pathology demonstrating inflammation and rimmed vacuoles. In addition, similar to the pathology observed in the brains of patients with Alzheimer's disease, the deposition of beta-amyloid and phosphorylated tau proteins in muscle fibers has been reported. These shared pathologic featu...

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Inclusion-body myositis

Inclusion-body myositis is the most frequent and disabling myopathy seen in patients over 50 years of age. The distinct clinical features that lead to correct diagnosis and inclusion-body myositis mimics are highlighted. Inclusionbody myositis has a complex pathogenesis in which autoimmune and inflammatory features coexist with elements of degeneration and abundant accumulations of various stre...

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ژورنال

عنوان ژورنال: Archives of Neurology

سال: 2001

ISSN: 0003-9942

DOI: 10.1001/archneur.58.8.1253